2. Signaling Pathways
  3. Epigenetics
  4. RNA MTase

RNA MTase

RNA Methyltransferase; METTL

RNA Methyltransferase catalyzes the RNA methylation modifications, including N6-methyladenosine (m6A) modification of mRNA, 5-methylcytosine (m5C) modification of RNA, N1-methyladenosine (m1A) modification of RNA, pseudouridine modification of RNA, N7-methylguanosine (m7G) modification of RNA, and 2'-O-methyluridine (Um) modification of RNA. RNA Methyltransferase regulates the gene expression, affects the expression of immune checkpoint proteins, and participates in the cell proliferation and differentiation. RNA Methyltransferasecan be divided into two groups: m6A methyltransferases such as METTL3/14, WTAP, VIRMA/KIAA1429, and the other methyltransferases such as NSun2, PCIF1, METTL16, etc. RNA Methyltransferasedysfunction could lead to tumor development, drug resistance, immune escape, or other metabolic and neurological diseases[1][2].

RNA MTase Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158301
    MY-1B
    		Inhibitor 99.94%
    MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.
    MY-1B